Micky van de Ven Brace Halts The Toffees' Run at Brand New Stadium
The Dutch defender emerged as the first defender to score two goals in a Premier League match for Tottenham since Jan Vertonghen in spring 2013.
At a glance
Micky Van de Ven nods home two times in opening period
Everton's defender has goal ruled after video check
Senegalese midfielder nets third in dying moments
The defeat is the Merseyside club's initial at their new ground
Micky van de Ven found the net on two occasions as Spurs extended their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at the dockside location, having left Goodison Park behind after 133 years at the conclusion of last season.
But Tottenham's leader Van de Ven pounced twice from corners in the first half to place their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker Richarlison - headed home a final goal to put the game to bed.
Jake O'Brien thought he had levelled the tally five minutes after the defender's opener, directing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a number of chances, while Vicario made a succession of excellent saves to ensure the London club went five matches on the road without defeat in the English top flight.
But the VAR stepped in, instructing the match official to review the goal on the pitchside monitor and the referee ruled that the winger and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's team into third place in the Premier League, five points off north London rivals and leaders the Gunners.
The Merseyside club stay 14th and sit six points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at both ends of pitch
After a uninspiring weekday performance in the European competition against the French side, where they mustered a mere attempts on goal, the manager opted for the French striker up front instead of ex-Everton forward the Brazilian.
The new arrival was unable to make much of an impact before being replaced for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the end.
Centre-back the Dutchman transformed into an offensive threat to be feared.
Spurs' opening strike came from a well-worked set-piece play, with the midfielder directing the ball toward the face of goal for an unmarked the defender to head home.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - added his second in first-half stoppage time as he rose above Jordan Pickford to nod in.
The Dutchman was just as outstanding in defensive duties, combining effectively with his defensive colleague as the pair handled superbly with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Toffees lacking finishing touch
The club's recent stadium had been a happy hunting ground, but it appears the novelty may have worn off slightly and supporters headed to the exits after the midfielder's final goal for Tottenham.
The end in Everton's winning streak at home won't be a massive concern for the manager, but their attacking woes are.
Beto and the other striker - the Toffees' two recognised centre-forwards - had netted only a single goal combined before the weekend's outing.
And they were unable to add to that poor tally on a wet and gloomy evening on Merseyside.
Beto's form was summed up when he chose to overhead kick a golden opportunity from close range, even with having room and opportunity to reposition for a simpler shot that would have challenged Vicario.
Barry, as well, failed to make an impact after coming on for the starter in the 65th minute.
It wasn't for a lack of chance. Most of Everton's offensive moves came through Grealish and the forward, who tirelessly whipped threatening crosses into the Spurs box.
What next for both teams?
The Toffees: The team head to the Stadium of Light in the top flight on early November at 8 PM.
Tottenham: The London club travel to St James' Park on late October for their next round League Cup match against the Magpies.